Chelsea Lately

Bradley Trevor Greive

Australian author Bradley Trevor Greive is on the guest list.

Adam Scott

Adam Scott is interviewed.

Kristen Bell

Kristen Bell talks up Season 3 of "House of Lies."

Idris Elba

Idris Elba is on the guest list, along with panelists Nick Swardson, Sarah Colonna and Michael Rosenbaum.

Amy Adams

Amy Adams is interviewed. On the panel: Moshe Kasher; Fortune Feimster; Dov Davidoff.

Zosia Mamet

An interview with Zosia Mamet. Also: Heather McDonald, Julian McCullough and Gary Valentine are on the panel.

Taylor Schilling

Taylor Schilling is interviewed. On the panel: Giulia Rozzi; Josh Wolf; Loni Love.

John Leguizamo

John Leguizamo promotes his movie "Ride Along." On the panel: Leah Remini; Mary McCormack; Whitney Cummings.

Kendall & Kylie Jenner

Kendall and Kylie Jenner promote the Season 9 premiere of "Keeping Up With the Kardashians."

Heather Graham

Heather Graham is interviewed. On the panel: John Caparulo, Claire Titelman and Ross Mathews.

Emmy Rossum

Emmy Rossum talks about Season 3 of "Shameless." Ben Gleib is on the panel, along with April Richardson and Ryan Stout.

David Spade

David Spade ("The Spoils of Babylon") is on the guest list.

Gabourey Sidibe

Gabourey Sidibe talks about her role on "American Horror Story: Coven." On the panel: Kerri Kenney-Silver; Natasha Leggero; Bobby Lee.

Timothy Olyphant

Timothy Olyphant chats about Season 5 of "Justified." On the panel: Michael Yo; Jamie Lee; Ross Mathews.

Andy Samberg

Andy Samberg is interviewed. On the panel: Moshe Kasher; Loni Love; and Gary Valentine.

Gabrielle Union

Gabrielle Union is interviewed. On the panel: Ron G; Heather McDonald; Ian Karmel.

Emma Roberts

Emma Roberts is interviewed. On the panel: Chris Franjola; Sarah Colonna; Dustin Ybarra.

Vanessa Hudgens

Vanessa Hudgens is interviewed. On the panel: John Caparulo; Fortune Feimster; Julian McCullough.

Michelle Monaghan

Michelle Monaghan ("True Detective") is on the guest list. Panelists: Natasha Leggero; Sarah Tiana; Whitney Cummings.

Mariska Hargitay

Mariska Hargitay is interviewed. On the panel: Jo Koy; Janine Brito; Ross Mathews.

Emma Kenney

Emma Kenney ("Shameless") is on the guest list. Panelists: Brody Stevens; Jen Kirkman; Kurt Braunohler.

McG

Director McG ("3 Days to Kill"). Also: Jeff Wild, Cameron Esposito and Matt Braunger are on the panel.

Sharon Osbourne

Sharon Osbourne.

Fashion Week

Chelsea celebrates Fashion Week. On the panel: Eliza Skinner; Lovi Love; Ryan Stout.

Alison Brie

Alison Brie is interviewed. On the panel: Kerri Kenney-Silver; Liza Treyger; Josh Wolf.

Demi Lovato

Demi Lovato is interviewed.

Ross Mathews Hosts, Jackie Collins

Guest host Ross Mathews

Alex Pettyfer

Alex Pettyfer is on the guest list.

Scott Speedman

Scott Speedman talks about his role in the comedy "Barefoot."

Kurt Russell

Kurt Russell chats about starring in "The Art of the Steal." On the panel: Sarah Colonna, Moshe Kasher and Fortune Feimster.

Julianne Moore

Julianne Moore appears in support of her film "Non-Stop." On the panel: Jen Kirkman, Beth Stelling and Jo Koy.

Sarah Paulson

Sarah Paulson is interviewed. On the panel: John Caparulo, Morgan Murphy and April Richardson.

Tara Lipinski & Johnny Weir

Figure skaters Tara Lipinski and Johnny Weir are interviewed. Also: Dov Davidoff, Whitney Cummings and Tone Bell are on the panel.

Michelle Dockery

Michelle Dockery of "Downton Abbey" is interviewed. On the panel: Kurt Braunohler, Fortune Feimster and Dustin Ybarra.

Cameron Diaz

Cameron Diaz chats about writing "The Body Book."

Gabourey Sidibe Hosts, Kid Cudi

Guest host Gabourey Sidibe

Khloé Kardashian Hosts, Justin Willman

Guest host Khloe Kardashian

Mary McCormack Hosts, Allison Janney

Guest host Mary McCormack

Minnie Driver

Minnie Driver is interviewed.

Emily Mortimer

Chelsea chats with Emily Mortimer about the HBO comedy series "Doll & Em."

Adam Levine

Adam Levine is interviewed.

Tyler Perry

A pastor thinks the movie "Frozen" has a gay agenda, Steven Tyler is allegedly dating his younger assistant, passengers on a Carnival Cruise want lifetime retribution, and from "Tyler Perry's Single Moms Club" Tyler Perry is here.

Adam Carolla

L.A had an earth quake this morning, the Malaysian airplane is still missing, Guinness beer pulls out of Saint Patrick's Day Parade, and from "Catch a Contractor" Adam Carolla is here.

Theo James

The Pope refused to meet with Russell Crowe, Billy D Williams performed on "Dancing With The Stars", the couple from "Little Couple, Big World" are separating and from "Divergent" Theo James is here.

Geoff Stults

George Clooney has a new girlfriend, John Mayor is sueing Charlie Sheen's friend, The Duke porn star is getting rich, and from "Enlisted" Geoff Stults is here.

Shaun White

Johnny Weir and his husband split up, Selfies are causing a rise in plastic surgery, Is Malaysian Flight 370 somewhere off the coast of Australia, and snowboard champion Shaun White is here.

Drew Brees

Drew Brees is interviewed.

Jayma Mays

Jayma Mays is interviewed.

Rick Ross

Rapper Rick Ross is interviewed.

Bradley Trevor Greive

Bradley Trevor Greive stops by with cute baby animals.

Demián Bichir

Demián Bichir.

Mark Cuban

Mark Cuban is interviewed.

Don Cheadle

Don Cheadle is interviewed.

Mindy Kaling

Mindy Kaling is interviewed.

Jamie Foxx

Jamie Foxx is interviewed. Also: John Caparulo, Beth Stelling and Brad Wollack appear on the panel.

Sebastian Stan

Sebastian Stan chats about his role in "Captain America: The Winter Soldier." On the panel: Kerri Kenney-Silver; Dustin Ybarra; and Heather McDonald.

Nikolaj Coster-Waldau

Nikolaj Coster-Waldau is interviewed.

Amy Schumer

Comedian Amy Schumer is interviewed. On the panel: April Richardson; Sarah Colonna; and Ross Mathews.

Marlon Wayans

Marlon Wayans is interviewed.

Ellie Goulding

Singer-songwriter Ellie Goulding is interviewed. On the panel: Bobby Lee; Whitney Cummings; and Julian McCullough.

Brooklyn Decker

Brooklyn Decker is interviewed. On the panel: Michael Yo; Loni Love; and Matt Braunger.

Khloé Kardashian Hosts, Bob Saget

Guest host Khloe Kardashian

T.J. Miller Hosts, Wiz Khalifa

Guest host T.J. Miller

Loni Love Hosts, Mekhi Phifer

Guest hosts Loni Love

Mary McCormack Hosts, Ian Somerhalder

Guest host Mary McCormack

Giuliana & Bill Rancic

Giuliana and Bill Rancic are interviewed.

Hugh Dancy

Hugh Dancy ("Hannibal") is on the guest list.

Helen Hunt

Helen Hunt discusses her role in the film "Decoding Annie Parker."

Tyler Glenn

Neon Trees' frontman Tyler Glenn is interviewed.

2 Chainz

Rapper 2 Chainz is interviewed. On the panel: Julian McCullough; Brad Wollack; and Liz Carey.

Jane Lynch

Jane Lynch is interviewed. On the panel: Chris Franjola; April Richardson; Gary Valentine.

Arianna Huffington

Arianna Huffington is interviewed. On the panel: Jen Kirkman; Kevin Christy; and Josh Wolf.

Dave Franco

Dave Franco is interviewed. On the panel: Nick Thune; Ian Karmel; Heather McDonald.

Connie Britton

Connie Britton is interviewed.

Sandra Oh

Sandra Oh is interviewed.

Jason Priestley

Jason Priestley chats about his memoir.

Edie Falco

"Nurse Jackie" star Edie Falco is on the guest list.

Evan Peters

Evan Peters is on the guest list. On the panel: Ron Funches, Sarah Tiana and Brad Wollack.

Iggy Azalea

Australian rapper Iggy Azalea is interviewed. On the panel: Michael Yo; Bobby Lee; and Jo Koy.

Charlize Theron

Charlize Theron is interviewed.

Drew Barrymore & Adam Sandler

Drew Barrymore and Adam Sandler are interviewed.

Joel McHale

Joel McHale is interviewed.

Terry Crews

Terry Crews is interviewed.

Sarah Silverman

Sarah Silverman.

Lea Michele

Lea Michele is interviewed.

Kelly Osbourne

Kelly Osbourne is on the guest list.

Giovanni Ribisi

Giovanni Ribisi is interviewed. On the panel: Jeff Wild, Natasha Leggero and Josh Wolf.

Austin Mahone

Singer Austin Mahone is interviewed.

Colin Hanks

Colin Hanks is interviewed.

Lena Headey

Lena Headey is interviewed.

Channing Tatum

Chelsea chats with Channing Tatum.

Jenny Slate

Jenny Slate chats about her movie "Obvious Child." On the panel: Liza Treyger; Jen Kirkman; Julian McCullough.

Rob Riggle

Rob Riggle is interviewed. On the panel: Moshe Kasher; Fortune Feimster; and Bobby Lee.

Jason Biggs

Jason Biggs ("Orange Is the New Black") is interviewed.

Little Women: LA

The cast of the Lifetime reality series "Little Women: LA" are on the guest list. Panelists include Greg Fitzsimmons, Sarah Tiana and Julian McCullough.

Laverne Cox

Laverne Cox ("Orange Is the New Black"). On the panel: Chris Franjola; Michael Yo; Josh Wolf.

Meagan Good

Meagan Good appears in support of her movie "Think Like a Man Too." Also: Ben Gleib, Fortune Feimster and Ryan Stout are on the panel.

Kevin Hart

Kevin Hart is interviewed.

Jenna Dewan-Tatum

Jenna Dewan-Tatum chats about Season 2 of her Lifetime drama "Witches of East End."

Gabriel Iglesias

Comedian Gabriel Iglesias is on the guest list.

Chris Rock

Chris Rock is interviewed. On the panel: Brody Stevens; April Richardson; and Jo Koy.

Eric Bana

Eric Bana is interviewed about his starring role in the thriller "Deliver Us From Evil."

Melissa McCarthy

Melissa McCarthy is interviewed. On the panel: Jeff Wild; Loni Love; Brad Wollack.

Susan Sarandon

Susan Sarandon is interviewed. On the panel: Chris Franjola; Arden Myrin; Kurt Braunohler.

Ben Falcone

Bel Falcone is interviewed.

Chrissy Teigen

Model Chrissy Teigen is interviewed. On the panel: Josh Wolf; Loni Love; Gary Valentine.

Dane Cook

Dane Cook is on the guest list. On the panel: Ben Gleib; Bobby Lee; Ross Mathews.

Cameron Diaz

Cameron Diaz is interviewed. On the panel: Mary McCormack; Whitney Cummings; Julian McCullough.

Dean Norris

Dean Norris ("Under the Dome") is interviewed.

Lela Loren

Lela Loren is interviewed.

Frank Grillo

Frank Grillo, star of "The Purge: Anarchy," is interviewed.

Natasha Lyonne & Uzo Aduba

Natasha Lyonne and Uzo Aduba, stars of "Orange Is the New Black," are interviewed.

TBA

John C. Reilly

John C. Reilly is interviewed.

Kelsey Grammer

Kelsey Grammer is interviewed.

Chris Pratt

Chris Pratt is interviewed.

TBA

Jake Owen

Country music artist Jake Owen is on the guest list.

Ethan Hawke

Ethan Hawke is interviewed.

Chandler Parsons

NBA player Chandler Parsons.

Megan Fox

Megan Fox is interviewed.

Liv Tyler

Liv Tyler ("The Leftovers") is interviewed.

Live Finale

In her opening monologue, host Chelsea Handler talks about what she did today at the studio on this the last day of the show, including the last communal shower she had in the Chelsea Lately shower facility. Chelsea and Chuy bring on her current stable of round table regulars. What Chelsea believes is going to be three of her closest celebrity friends, Mary McCormack - her best friend - Jennifer Aniston, and Sandra Bullock, providing a gracious send-off ends up being what they hope will be more useful for Chelsea's life. Chelsea's ex-lover 50 Cent and G-Unit perform their new single, "Watch Me". Chuy, via a prepared video, talks about what this show and Chelsea have meant to him. Miley Cyrus, in tribute to it being the last show, performs the pop classic, "It's Over". And many of Chelsea's musical friends, and some non-musical friends, help her serenade E!, to who she is grateful for the past seven years.